TABLE 1.
ld | lo | ||||||
---|---|---|---|---|---|---|---|
T (°C) | Tie-line | xPC | xSM | xchol | xPC | xSM | xchol |
23 | On tie-triangle | 69 | 27 | 4 | 24 | 42 | 34 |
Containing 1:1:1 | 74–69 | 19–27 | 6–4 | 25–26 | 36–35 | 39–40 | |
37 | On tie-triangle | 36 | 59 | 6 | 1 | 73 | 26 |
Containing 1:1:1 | 69–57 | 18–33 | 13–10 | 14–19 | 42–33 | 44–48 | |
4 | Containing 1:1:1 | 60 | 26 | 14 | 16 | 38 | 46 |
Containing 8:1:1 | 81 | 10 | 9 | 57 | 18 | 25 |
SM is PSM and PC is POPC. The compositions given are the extremes of the tie-lines depicted in Fig. 7, A and B. At 4°C (results from Schroeder et al. (1994)), PC is from bovine liver and SM is from bovine brain, and lo is taken as the TX100 insoluble fraction and ld as the soluble fraction of the initial liposomes.