. 2003 Oct;85(4):2732–2745. doi: 10.1016/s0006-3495(03)74696-7

TABLE 2.

Parameter values that are specific to individual models

		Value
Parameter	Description	Blockade model	Competition model	Affinity model
k_{off_het}	EGF dissociation rate constant from heterodimers	0.5 min⁻¹	0.5 min⁻¹	0.1–2.5 min⁻¹
k_c,R1E,het	EGF-EGFR/ERC coupling rate constant when in a heterodimer	0	1 × 10⁻³ (#/cell)⁻¹ min⁻¹	1 × 10⁻³ (#/cell)⁻¹ min⁻¹
k_c,R2E	HER2/ERC coupling rate constant	0	1 × 10⁻³ (#/cell)⁻¹ min⁻¹	0
k_c,R2E,het	HER2/ERC coupling rate constant when in a heterodimer	0	1 × 10⁻³ (#/cell)⁻¹ min⁻¹	1 × 10⁻³ (#/cell)⁻¹ min⁻¹
k_u,R2E	HER2/ERC uncoupling rate constant	0	0.1 min⁻¹	0