Table 5.
Sensitivities for malignant lesions, calculated from ratings in the reader evaluation, (a) of individual sequences, (b) of the five best performing combinations of two sequences and (c) of the five best performing combinations of three sequences
| Sequence names | Reader 1 | Reader 2 | Reader 3 | Avg |
|---|---|---|---|---|
| (a) Individual sequences | ||||
| FLAIR (head only) | 100 [NA; NA] | 100 [NA; NA] | 100 [NA; NA] | 100.0 |
| DWI | 84.2 [72.7; 91.4] | 86.8 [75.7; 93.4] | 86.8 [75.7; 93.3] | 86.0 |
| TIRM | 81.6 [61.3; 92.5] | 63.5 [50.6; 74.2] | 76.3 [60.3; 87.2] | 73.7 |
| T1CE | 78.9 [63.7; 88.9] | 63.2 [49.0; 79.6] | 76.3 [61.2; 86.8] | 72.8 |
| HASTE | 76.3 [54.2; 89.8] | 55.3 [40.3; 69.3] | 65.8 [52.7; 76.9] | 65.8 |
| T1noCE | 60.5 [40.3; 77.7] | 55.3 [39.6; 70.0] | 73.7 [54.3; 86.8] | 63.2 |
| T1cor | 57.3 [40.0; 73.9] | 47.4 [32.5; 62.7] | 52.6 [36.7; 68.0] | 52.6 |
| (b) Combinations of two sequences | ||||
| DWI + FLAIR | 94.7 [84.3; 98.4] | 94.7 [84.3; 98.4] | 97.4 [88.2; 99.5] | 95.6 |
| DWI + T1CE | 92.1 [82.1; 96.7] | 94.7 [81.3; 98.7] | 92.1 [82.1; 96.7] | 93.0 |
| DWI + HASTE | 92.1 [81.5; 96.9] | 92.1 [78.5; 97.4] | 89.5 [79.4; 94.9] | 91.2 |
| DWI + TIRM | 89.5 [77.5; 95.4] | 89.5 [79.4; 94.9] | 92.1 [81.5; 96.9] | 90.4 |
| TIRM + T1CE | 94.7 [84.3; 98.4] | 81.6 [66.3; 90.9] | 94.7 [84.3; 98.4] | 90.4 |
| (c) Combinations of three sequences | ||||
| FLAIR + DWI + HASTE | 100.0 [NA; NA] | 100.0 [NA; NA] | 100.0 [NA; NA] | 100.0 |
| FLAIR + DWI + T1CE | 100.0 [NA; NA] | 100.0 [NA; NA] | 100.0 [NA; NA] | 100.0 |
| FLAIR + DWI+T1cor | 97.4 [82.4; 99.7] | 97.4 [82.4; 99.7] | 100.0 [NA; NA] | 98.2 |
| FLAIR + DWI + T1noCE | 94.7 [84.3; 98.4] | 97.4 [88.2; 99.5] | 100.0 [NA; NA] | 97.4 |
| FLAIR + DWI + TIRM | 94.7 [84.3; 98.4] | 97.4 [88.2; 99.5] | 97.4 [88.2; 99.5] | 96.5 |
| (d) Combinations of three sequences without FLAIR | ||||
| DWI + T1CE + TIRM | 97.4 [81.4; 99.7] | 94.7 [80.5; 98.7] | 97.4 [81.4; 99.7] | 96.5 |
| DWI + T1CE + T1cor | 94.7 [80.5; 98.7] | 94.7 [80.5; 98.7] | 92.1 [81.7; 96.8] | 93.9 |
| DWI + HASTE + TIRM | 94.7 [79.9; 98.8] | 92.1 [77.9; 97.5] | 94.7 [79.9; 98.8] | 93.9 |
| DWI + HASTE + T1CE | 94.7 [83.8; 98.4] | 94.7 [80.5; 98.7] | 92.1 [81.7; 96.8] | 93.9 |
| DWI + T1CE + T1noCE | 92.1 [81.7; 96.8] | 94.7 [80.5; 98.7] | 92.1 [81.7; 96.8] | 93.0 |
Although sensitivities were calculated for all possible sequence combinations, only the five best-performing combinations are displayed here
FLAIR fluid-attenuated inversion recovery, DWI diffusion-weighted imaging with b-value 900, TIRM turbo-inversion recovery-magnitude, T1CE contrast-enhanced T1 VIBE Dixon, HASTE half Fourier-acquisition single-shot turbo spin echo, T1noCE T1 VIBE Dixon without contrast agent, T1cor T1 TSE in coronal plane, NA not available, Avg average