Table 2.

Association results of DDH GWASs

rsID	CHR	POS	Gene	Allele1	Allele2	Freq1	OR(95%CI)	P-value	Direction	HetP-Val
Hip dysplasia
rs1704995	6	33187688	COL11A2	T	C	0.817	1.48(1.29–1.71)	4.8 × 10−8	+++	0.21
rs10241320	7	71258598	CALN1	T	C	0.180	1.56(1.35–1.79)	7.1 × 10−10	+++	0.46
rs7168702	15	50959151	TRPM7	T	C	0.989	0.17(0.09–0.31)	1.2 × 10−8	−−−	0.69
DDH
rs142273463	4	177942225	VEGF-C	A	G	0.994	0.12(0.06–0.23)	1.1 × 10−10	−−−−−−	0.19
rs146711505	6	1531009	FOXC1	T	TTG	0.234	0.73(0.66–0.82)	4.7 × 10−8	−−−−−−	0.62
rs147057560	9	107067481	SMC2	T	G	0.991	0.19(0.12–0.32)	2.1 × 10−10	−−−−−−	0.39
rs78572420	12	47109115	SLC38A4	A	G	0.775	0.74(0.66–0.82)	3.9 × 10−8	−−−−−−	0.070
rs7168702	15	50959151	TRPM7	T	C	0.990	0.20(0.12–0.33)	8.1 × 10−10	−−−+−−	0.30
Meta analysis JPN and UK DDH
rs993471	1	103385373	COL11A1	A	G	0.639	1.23(1.14–1.33)	2.2 × 10−8	+++++++	0.59
rs143384	20	34025756	GDF5	A	G	0.686	1.39(1.29–1.50)	5.8 × 10−17	+++++++	0.33

DDH developmental dysplasia of the hip, CHR chromosome, POS position (position base pair in genome build hg19), Allele1 effect allele, Allele2 alternative allele, Freq1 frequency for effect allele across this analysis, OR odds ratio, CI confidence interval, P-value meta-analysis P-value; Direction, summary of effect direction for each study (Hip dysplasia; GWAS set1/GWAS set2/GWAS set3, JPN DDH Japanese hip dysplasia GWAS set1/Japanese hip dysplasia GWAS set2/Japanese hip dysplasia GWAS set3/Japanese dislocated hip GWAS set1/Japanese dislocated hip GWAS set2/Japanese dislocated hip GWAS set3, Meta analysis JPN and UK DDH; UK-DDH GWAS /Japanese hip dysplasia GWAS set1/Japanese hip dysplasia GWAS set2/Japanese hip dysplasia GWAS set3/Japanese dislocated hip GWAS set1/Japanese dislocated hip GWAS set2/Japanese dislocated hip GWAS set3); HetPVal, P-value for heterogeneity statistic