TABLE 1.

Dissociation constants and thermodynamic data for binding of volatile general anesthetics to the four-α-helix bundle (Aα₂-L38M)₂

Anesthetic	Kd (μM)	ΔG° (kcal/mol)	ΔH° (kcal/mol)	ΔS° (eu)*
Halothane	60 ± 5	−5.7 ± 0.1	−7.7 ± 0.2	−6.9
Isoflurane	140 ± 10	−5.2 ± 0.1	−7.7 ± 0.1	−8.5
Sevoflurane	140 ± 10	−5.2 ± 0.1	−8.2 ± 0.2	−10.4
Enflurane	240 ± 10	−4.9 ± 0.1	−7.2 ± 0.1	−8.0

^*The entropy unit (eu) is cal/mol K.