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. 2026 Mar 16;17:1740765. doi: 10.3389/fendo.2026.1740765

Table 2.

The clinical outcomes of the patients in day 4 and day 5 group stratified by fertilization method.

Variables IVF P ICSI P
D4 D5 D4 D5
Cycles(n) 793 230 179 43
Clinical Pregnancy rate (%) 63.93(507/793) 58.70(135/230) 0.148 65.36 (117/179) 65.12 (28/43) 0.976
Implantation rate (%) 51.09(655/1282) 50.98(182/357) 0.970 51.49 (155/303) 57.14 (39/71) 0.567
Live birth rate (%) 53.09(421/793) 48.70(112/230) 0.240 55.31 (99/179) 51.16 (22/43) 0.624
Ectopic pregnancy rate (%) 0.39(2/507) 0.74(1/135) 0.508 0.85 (1/117) 0(0/28) 1.000
Multiple pregnancy rate (%) 29.59(150/507) 34.81(47/135) 0.242 32.48 (38/117) 39.29 (11/28) 0.494
Monozygotic twins rate (%) 1.58(8/507) 1.48(2/135) 1.000 0.85 (1/117) 3.57 (1/28) 0.350
Miscarriage rate (%) 15.58(79/507) 16.30(22/135) 0.839 11.97 (14/117) 21.43 (6/28) 0.318
Premature birth rate (%) 16.17(82/507) 16.30(22/135) 0.973 14.53 (17/117) 7.14 (2/28) 0.466
Stillbirth rate (%) 0(0/507) 0(0/135) / 0.85 (1/117) 0 (0/28) 1.000
Cesarean section rate (%) 57.99(294/507) 65.93(89/135) 0.095 58.97 (69/117) 67.86 (19/28) 0.387
Gestational week of delivery [weeks, M (Q1, Q3)] 38(37,39) 38(37,39) 0.067 38 (37,39) 38 (37,39) 0.584
Male/female ratio 0.99(267/273) 1.18(80/68) 0.320 0.97 (61/63) 1.31 (17/13) 0.463
Live birth weight [g, M (Q1, Q3)] 3000(2500, 3400) 2900(2550, 3388) 0.649 3200 (2600, 3500) 3000 (2663, 3188) 0.330
Cumulative live birth rate (%) 73.27 (581/793) 71.30 (164/230) 0.556 68.72 (123/179) 74.42 (32/43) 0.464