Fig. 4.

WTAP associates with profibrotic activation and module remodeling in fibroblasts. (A) Correlation bubble plot linking m⁶A regulators to fibroblast functional programs. (B) Scatter plots showing positive correlations between WTAP expression and response to fibroblast growth factor and fibroblast proliferation. (C) Violin plots comparing WTAP-high and WTAP-low fibroblasts for representative genes. (D) Volcano plot of differentially expressed genes between groups. (E) GO molecular function enrichment for WTAP-high cells. (F) GSEA showing enrichment of fibroblast proliferation, cell adhesion, and wound response. (G) Spatial feature plots of the cell type, WTAP, and pathway enrichment scores in IPF tissue sections. (H) hdWGCNA dendrogram identifying co-expression modules in fibroblasts. (I) Module eigengene expression across fibroblast cells. (J) Network of the turquoise module and top kME hub genes. (K) Functional enrichment of top turquoise-module genes. (L) Heatmap showing correlations between modules and fibroblast pathways. (M) Regulatory network linking transcription factors (TFs) to m⁶A writers and readers. (N) Global cell–cell communication network comparing WTAP-high versus WTAP-low states; edge thickness reflects the number of ligand–receptor interactions per cell type pair. (O) Differential heatmaps summarizing changes in interaction number and strength by sender–receiver pairs, with marginal bars showing totals across lineages