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. 2026 Mar 5;24:439. doi: 10.1186/s12967-026-07876-x

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — WTAP marks a fibroblast pseudotime shift from metabolic homeostasis to adhesion/migration and ECM remodeling. (A) Reclustering of fibroblasts into subclusters F1–F4. (B) Pseudotime projection of fibroblast differentiation trajectories. (C) Trajectory inference illustrating F1–F4 transition path. (D) Violin plots of WTAP expression and phenotypic-switching scores across subclusters. (E) Representative pathways (respiration, growth-factor response, phenotypic switching) mapped along pseudotime. (F) Segmented pseudotime heatmaps and GO enrichment of dynamic modules. (G) Correlation of WTAP with metabolic and adhesion-related terms. (H) Pseudotime expression dynamics of WTAP, JUN/JUNB, SDHC, PPP1R15A, and TSPO. (I) Correlation bubble plot showing WTAP association with transcriptional and metabolic regulators