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. Author manuscript; available in PMC: 2026 Apr 1.
Published in final edited form as: Exp Neurol. 2024 May 25;378:114838. doi: 10.1016/j.expneurol.2024.114838

Figure 4.

Figure 4.

Expression of the Prospero-related homeobox-1-positive (Prox-1+) granule cells in the hippocampal dentate gyrus after 1 week of antibody washout. Mice treated with anti-NMDAR antibodies developed an increased ectopic displacement of Prox-1+ granule cells in dentate hilus (DH) after 1 week of the antibody washout (A). The expression of the ectopic Prox-1+ cells in the DH of mice treated with anti-NMDAR antibodies was consistently higher than that in mice treated with control antibodies at all assessed bregma levels (B). The data represent mean ± SEM. **, p < 0.001, t-test; n = 7–8 mice per group. Representative microscopic images showing the Prox-1 immunoreactivity of the nootropic mature granule neuron in the hippocampal granule zone (GZ, arrow, and insert) and ectopic neurons in DH (circle) of mice treated with control antibodies (C) and anti-NMDAR antibodies (D). Scale bar: 50 μm (insert: 30 μm).