Table 1.
Summary of the memory test outcomes during the antibody washout in mice treated with anti-NMDAR and control antibodies.
| Assessments (weeks from IgG removal), units | Anti-NMDAR IgG | Control IgG | p-value |
|---|---|---|---|
| Memory test indexes, mean ± SEM | |||
| Object location (1), % | 43.2 ± 5.0 | 60.1 ± 3.9 | p = 0.02 |
| Y maze (1), % | 67 ± 3.7 | 66.4 ± 3.4 | p = 0.9 |
| Object location (3), % | 43.2. ± 5.7 | 63.1 ± 3.9 | p = 0.009 |
| Barnes maze, failure rate: trials 3 and 4 (4), % | 0 and 30 | 100 and 70 | p = 0.03 |
| Barnes maze, primary latency (4), sec | 55.1 ± 21.4 | 82.7 ± 18.7 | p = 0.35 |
| Barnes maze, total time in the target quadrant (4), sec | 86.2 ± 9.8 | 73.3 ± 8.0 | p = 0.32 |
| Barnes maze, time in the target quadrant after discovery of the hole (4), sec | 69.3 ± 14.6 | 43.6 ± 8.5 | p = 0.13 |
| Y maze (4), % | 55.0 ± 3.1 | 71.0 ± 2.3 | p = 0.0006 |