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The pH and zinc modulation of the KDC1-KAT1 current. (A) Acidic pHs determine a potentiation of the current of the KDC1-KAT1 channels. Compare this pH potentiation of the current with that induced on KAT1 by the same pH variation (B). At neutral pH, zinc potentiation of the dimeric current is even greater with respect to pH 5.6. On the contrary, the inhibition of the KAT1 current in the presence of zinc is not affected by the pH (see Table 1). Standard ionic solution.
