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. 2026 Mar 31;125(1):51. doi: 10.1007/s00436-026-08645-x

Table 5.

Selected differentially expressed unigenes (down and up) putatively between normal ticks and abnormal ticks

Predictive Function NR Annotation Regulation N_tick Abn_tick Log2 Fold change
(Abn_tick/N_tick)
P-value Gene ID
Reproduction/development TPA: ecdysone-induced protein 63 F 1 down 11. 99 0. 89 −3.76 0. 015 DN43239
juvenile hormone acid O-methyltransferase down 29. 78 5. 00 −2.57 0. 004 DN114954
craniofacial development protein 2 down 5. 47 0 -Inf 0. 046 DN23834
arylsulfatase B down 5. 80 0 -Inf 0. 038 DN61560
double-strand-break repair protein down 8460. 95 664. 47 −3.67 0. 011 DN3576
Hydrolyzation chitotriosidase-1 down 166. 52 37. 22 −2.16 0. 009 DN62451

Exoskeleton formation/

development

adult-specific rigid cuticular protein 15. 7 down 598. 11 62. 14 −3.27 0. 006 DN2986
cuticle protein 16. 8 down 78. 40 8. 27 −3.25 0. 035 DN140519
cuticle protein 10. 9 down 16. 76 3. 00 −2.48 0. 031 DN128394
glycine-rich cell wall structural protein 1. 0 down 166. 19 14. 85 −3.48 < 0. 001 DN9891
collagen alpha-1 (I) chain down 833. 90 115. 86 −2.85 < 0. 001 DN167182
Drug resistance cytochrome P450 2A12 down 32. 71 2. 78 −3.55 0. 030 DN28459
cytochrome P450 3A4 down 220. 09 52. 62 −2.06 0. 012 DN134629

Oxidant metabolism

/detoxification

glutathione S-transferase Mu 2 down 412. 91 3. 43 −6.91 0. 008 DN7352
Epsilon class glutathione S-transferase protein 1 down 24. 76 6. 12 −2.02 0. 027 DN3406
Defence zonadhesin down 7. 23 0 -Inf 0. 017 DN167776
ice-structuring glycoprotein down 1149. 76 35. 84 −5.00 0. 020 DN4689

Immunity

/antimicrobial

ctenidin-1 down 25. 52 0 -Inf < 0. 001 DN5799
lachesin down 288. 71 59. 42 −2.28 < 0. 001 DN19269
A disintegrin and metalloproteinase with thrombospondin motifs 12 down 114. 24 10. 68 −3.42 0. 032 DN2750
hemocytin down 9333. 85 3495. 35 −1.42 0. 004 DN566
complement factor B down 17. 24 0. 57 −4.91 < 0. 001 DN41024
N-acetylmuramoyl-L-alanine amidase down 12. 27 0. 94 −3.70 0. 013 DN8014
Blood feeding venom serine carboxypeptidase down 365. 28 0 -Inf 0. 034 DN1392
chymotrypsin-like protease CTRL-1 down 2357. 82 991. 78 −1.25 0. 004 DN3077
thromboxane-A synthase down 411. 53 15. 64 −4.72 0. 002 DN6323

Metabolism/

detoxification

sulfotransferase family cytosolic 1B member 1 down 564. 85 129. 67 −2.12 < 0. 001 DN826
sulfotransferase 1E1 down 72. 07 9. 91 −2.86 < 0. 001 DN30772
vitamin D 25-hydroxylase down 11. 23 0. 29 −5.29 0. 017 DN53846
alpha-tocopherol transfer protein down 304. 37 79. 28 −1.94 0. 001 DN686
Response to Stress Conditions heat shock protein 90 − 2 up 0 11. 99 Inf 0. 001 DN60626
Blood feeding kunitz-type serine protease inhibitor 6 up 2. 038 110. 32 5.76 < 0. 001 DN1721
serine protease inhibitor swm-1 up 0. 34 8. 30 4.61 0. 026 DN42504
venom peptide MmKTx up 2. 71 47. 54 4.13 < 0. 001 DN8449
chymotrypsin inhibitor up 8. 55 118. 47 3.79 0. 033 DN160582
cystatin-A2 up 338. 10 2699. 58 3.00 0. 023 DN1185
BPTI/Kunitz domain-containing protein up 4. 10 24. 58 2.58 0. 021 DN12498
boophilin-H2 up 370. 08 1478. 30 2.00 < 0. 001 DN8393
Antimicrobial antimicrobial peptide microplusin up 746. 75 28,927. 73 5.28 0. 003 DN42436
defensin up 0. 66 22. 09 5.05 0. 020 DN146342
lysozyme c-1 up 107. 52 2121. 36 4.30 0. 021 DN1310
TPA: lysozyme f2 up 18. 25 82. 91 2.18 0. 012 DN138005
Protein Degradation transmembrane protease serine 9 up 146. 26 1838. 24 3.65 < 0. 001 DN6118
serine proteinase stubble up 1. 02 9. 68,307 3.24 0. 046 DN11708
procathepsin L up 8. 19 55. 41 2.76 0. 030 DN20844
cathepsin D up 63. 60 248. 41 1.97 < 0. 001 DN120291