Table 1.
Univariate and multivariate Cox regression analysis of factors associated with overall survival
| Variables (n = 22,079) | Log Rank test | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| Mean survival time (95% CI) | χ2 | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | 36.109 | < 0.001 | < 0.001 | < 0.001 | |||
| Female | 163.2 (160.4–166.1) | Reference | Reference | ||||
| Male | 153.4 (151.2–155.6) | 1.155 (1.102–1.210) | < 0.001 | 1.252 (1.193–1.313) | < 0.001 | ||
| Age (y) | 688.546 | < 0.001 | < 0.001 | < 0.001 | |||
| 20–39 | 187.0 (180.1- | Reference | Reference | ||||
| 40–59 | 193.9) | 1.059 (0.943–1.189) | 0.334 | 1.142 (1.016–1.283) | 0.026 | ||
| 60–79 | 180.3 (177.9–182.7) | 1.991 (1.776–2.231) | < 0.001 | 2.206 (1.965–2.478) | < 0.001 | ||
| Year of diagnosis | 129.4 (127.0–131.8) | 179.196 | < 0.001 | < 0.001 | < 0.001 | ||
| 2000–2005 | 142.8 (139.6–145.9) | Reference | Reference | ||||
| 2006–2010 | 126.6 (124.6–128.6) | 0.858 (0.809–0.909) | < 0.001 | 0.847 (0.797–0.900) | < 0.001 | ||
| 2011–2015 | 100.3 (99.2–101.4) | 0.743 (0.698–0.790) | < 0.001 | 0.701 (0.656–0.749) | 0.001 | ||
| 2016–2021 | 62.9 (62.4–63.4) | 0.607 (0.558–0.660) | < 0.001 | 0.579 (0.530–0.632) | < 0.001 | ||
| Race | 1.794 | 0.180 | < 0.001 | < 0.001 | |||
| White | 157.3 (155.4–159.2) | Reference | Reference | ||||
| Black | 139.8 (133.7–145.9) | 1.314 (1.217–1.420) | < 0.001 | 1.287 (1.191–1.392) | < 0.001 | ||
| Other | 168.3 (163.0–173.6) | 0.867 (0.803–0.935) | < 0.001 | 0.934 (0.865–1.009) | 0.084 | ||
| Marital status | 47.353 | < 0.001 | < 0.001 | < 0.001 | |||
| Single | 150.0 (145.5–154.5) | Reference | Reference | ||||
| Married | 165.8 (163.7–168.0) | 0.803 (0.756–0.854) | < 0.001 | 0.735 (0.691–0.782) | < 0.001 | ||
| Other | 134.5 (130.7–138.3) | 1.224 (1.141–1.313) | < 0.001 | 1.038 (0.965–1.116) | 0.313 | ||
| Histologic type | 61.898 | < 0.00 | < 0.001 | < 0.001 | |||
| Adenocarcinoma | 158.6 (156.8–160.4) | 1 | Reference | 1 | Reference | ||
| Mucous tumor | 135.0 (128.2–141.9) | 1.396 (1.280–1.523) | < 0.001 | 1.183 (1.084–1.291) | < 0.001 | ||
| Other | 131.8 (115.7–148.0) | 1.434 (1.156–1.778) | 0.001 | 1.463 (1.179–1.816) | 0.001 | ||
| Median household income ($) | 89.981 | < 0.001 | Reference | Reference | |||
| 0–599,999 | 143.0 (138.8–147.1) | 0.859 | < 0.001 | 0.858 | < 0.001 | ||
| 600,000–799,999 | 155.4 (152.7–158.1) | (0.808–0.913) | < 0.001 | (0.807–0.912) | < 0.001 | ||
| 800,000–999,999 | 161.0 (157.8–164.2) | 0.792 (0.741–0.846) | < 0.001 | 0.807 (0.754–0.863) | < 0.001 | ||
| > 1,000,000 | 170.8 (166.2–175.4) | 0.686 (0.632–0.745) | < 0.001 | 0.721 (0.663–0.784) | < 0.001 | ||
| T stage | 323.906 | < 0.001 | < 0.001 | < 0.001 | |||
| T0 | 79.4 (45.5–113.3) | Reference | Reference | ||||
| T1 | 189.1 (179.0–199.1) | 0.417 (0.103–1.689) | 0.221 | 0.264 (0.065–1.070) | 0.062 | ||
| T2 | 182.6 (176.5–188.6) | 0.492 (0.123–1.973) | 0.317 | 0.296 (0.074–1.188) | 0.086 | ||
| T3 | 158.1 (156.2–160.1) | 0.718 (0.180–2.871) | 0.639 | 0.475 (0.119–1.903) | 0.293 | ||
| T4 | 122.8 (117.5–128.1) | 1.226 (0.306–4.907) | 0.774 | 0.816 (0.204–3.269) | 0.774 | ||
| N stage | 225.516 | < 0.001 | < 0.001 | < 0.001 | |||
| N0 | 163.2 (160.5–165.8) | Reference | Reference | ||||
| N1 | 163.6 (160.9–166.4) | 1.002 (0.952–1.054) | 0.947 | 1.235 (1.171–1.303) | < 0.001 | ||
| N2 | 128.9 (124.7–133.1) | 1.691 (1.593–1.796) | < 0.001 | 2.040 (1.918–2.170) | < 0.001 | ||
| Treatment modality | 32.517 | < 0.001 | < 0.001 | < 0.001 | |||
| PreORT group | 159.5 (157.3–161.7) | Reference | Reference | ||||
| PostORT group | 150.3 (147.3–153.3) | 1.146 (1.091–1.202) | < 0.001 | 0.996 (0.944–1.050) | 0.871 | ||
| Chemotherapy | 63.775 | < 0.001 | < 0.001 | < 0.001 | |||
| No | 126.4 (118.3–134.5) | Reference | Reference | ||||
| Yes | 158.3 (156.5–160.1) | 0.657 (0.593–0.729) | < 0.001 | 0.748 (0.673–0.832) | < 0.001 | ||
| AJCC stage | 48.324 | < 0.001 | < 0.001 | * | * | ||
| II | 163.2 (160.5–165.8) | Reference | |||||
| III | 153.6 (151.3–155.9) | 1.173 (1.120–1.229) | < 0.001 | ||||
*Degree of freedom reduced because of constant or linearly dependent covariates
Bold indicates that P < 0.05.
CI, confidence interval; HR, Hazard ratio; PreORT, preoperative radiotherapy; PostORT, postoperative radiotherapy; AJCC, American Joint Committee on Cancer