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. 2004 Feb;86(2):1028–1041. doi: 10.1016/s0006-3495(04)74178-8

FIGURE 5.

FIGURE 5

Differential cleavage plots comparing the susceptibility of the different DNA restriction fragments to DNase I cutting in the presence of CGP 40215A (•), berenil (□), or pentamidine (○) at 5 μM. Negative values correspond to a ligand-protected site and positive values represent enhanced cleavage. Vertical scales are in units of ln(fa) − ln(fc), where fa is the fractional cleavage at any bond in the presence of the drug and fc is the fractional cleavage of the same bond in the control, given closely similar extents of overall digestion. Only the region of the restriction fragment analyzed by densitometry is shown.