Table 4.

Diagnostic performance across subgroups With and without AI.

Sub-group	Without AI	With AI	Δ95 % CI	P-value
AUROC
Age < 50 y	0.906	0.946	+0.041 (0.017–0.065)	0.002
Age ≥ 50 y	0.911	0.953	+0.043 (0.014–0.073)	0.004
Dense breasts	0.902	0.944	+0.042 (0.021–0.064)	<.001
Calcifications present	0.911	0.956	+0.045 (0.008–0.085)	0.012
Calcifications absent	0.912	0.947	+0.035 (0.012–0.059)	0.002
Tumor size ≤ 2 cm	0.889	0.933	+0.044 (0.019–0.070)	<.001
Tumor size 2–5 cm	0.891	0.952	+0.060 (–0.002–0.129)	0.062
Irregular shape	0.891	0.942	+0.050 (0.028–0.073)	<.001
General radiologists¹	0.922	0.955	+0.034 (0.010–0.057)	0.003
Breast-imaging specialists¹	0.904	0.946	+0.042 (0.015–0.070)	0.002
Sensitivity
Age < 50 y	93.1	96	+2.9 (–2.3 to 8.1)	0.263
Age ≥ 50 y	95.2	96.5	+1.3 (–3.5 to 6.0)	0.599
Dense breasts	93.5	95.5	+2.0 (–2.2 to 6.2)	0.346
Calcifications present	94.4	96.7	+2.3 (–2.3 to 6.8)	0.311
Calcifications absent	93.9	95.8	+1.9 (–3.6 to 7.3)	0.500
Tumor size ≤ 2 cm	92.1	94	+1.9 (–3.7 to 7.5)	0.502
Tumor size 2–5 cm	96.2	99	+2.8 (–1.7 to 7.3)	0.159
Irregular shape	94.3	96.1	+1.9 (–1.8 to 5.5)	0.304
General radiologists¹	94.8	95.7	+1.0 (–2.8 to 4.7)	0.611
Breast-imaging specialists¹	93	97.3	+4.3 (–0.2 to 8.7)	0.060
Specificity
Age < 50 y	64.8	72	+7.3 (–2.3 to 16.9)	0.140
Age ≥ 50 y	61.6	70.2	+8.6 (–6.8 to 24.0)	0.277
Dense breasts	65.7	73.1	+7.4 (–1.8 to 16.5)	0.117
Calcifications present	66.7	70.5	+3.8 (–23.7 to 31.4)	0.784
Calcifications absent	63.6	71.7	+8.0 (–0.5 to 16.6)	0.067
Tumor size ≤ 2 cm	64.9	72.5	+7.6 (–0.7 to 15.9)	0.074
Tumor size 2–5 cm	44.4	52.8	+8.3 (–31.0 to 47.7)	0.679
Irregular shape	38.9	52	+13.1 (–3.9 to 30.1)	0.134
General radiologists¹	58.1	73.3	+15.1 (6.6 to 23.6)	0.001
Breast-imaging specialists¹	75.6	68.2	–7.4 (–16.5 to 1.8)	0.118

AUROC, area under the receiver operating characteristic curve, CI = confidence interval.