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. 2004 Feb;86(2):690–704. doi: 10.1016/S0006-3495(04)74148-X

TABLE 2.

Comparison of pKa of residues belonging to the loop 3 cluster

	Network-1				Network-2
	Protein dielectric = 4		Protein dielectric = 20		Protein dielectric = 4		Protein dielectric = 20
Residues	pKa_intrinsic	pKa_apparent	pKa_intrinsic	pKa_apparent	pKa_intrinsic	pKa_apparent	pKa_intrinsic	pKa_apparent
Tyr-22	12.6	>14	10.6	>14	13.4	>14	10.8	>14
Asp-117	4.3	1.4	4.8	4.1	4.3	6.2	4.8	4.4
Glu-296	8.6	>14	5.1	8.4	8.0	>14	4.9	8.8
Tyr-310	>14	>14	11.4	>14	>14	>14	11.3	>14
Asp-312	2.9	7.5	3.7	2.4	1.4	<1	3.4	1.4