Table 4.
ACE2 allele and genotype frequencies in MS patients and healthy controls.
| SNP | Allele/genotype | MS patients (N = 498) N (%) |
Healthy controls (N = 504) N (%) |
Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | ||||
| rs2074192 |
T C |
402 (40.4) 594 (59.6) |
323 (32.0) 685 (68.0) |
< 0.001 | 0.697 (0.580–0.837) | – | – |
|
TT CT CC |
114 (22.9) 174 (34.9) 210 (42.2) |
82 (16.3) 159 (31.5) 263 (52.2) |
0.003 0.188 0.001 |
Ref 1.270 (0.890–1.814) 1.741 (1.243–2.438) |
< 0.001 < 0.001 < 0.001 |
Ref 2.297 (1.488–3.544) 1.991 (1.367–2.898) |
|
|
TT CT + CC |
114 (22.9) 384 (77.1) |
82 (16.3) 422 (83.7) |
0.008 | 1.528 (1.114–2.095) | < 0.001 |
Ref 2.078 (1.448–2.981) |
|
| rs2285666 |
T C |
179 (18.0) 817 (82) |
218 (21.6) 790 (78.4) |
0.040 | 1.26 (1.01–1.57) | – | – |
|
TT CT CC |
34 (6.8) 111 (22.3) 353 (70.9) |
53 (10.5) 112 (22.2) 339 (67.3) |
0.114 0.091 0.037 |
Ref 0.647 (0.391–1.072) 0.616 (0.391–0.972) |
0.441 0.818 0.580 |
Ref 1.072 (0.593–1.939) 0.865 (0.518–1.444) |
|
|
TT CT + CC |
34 (6.8) 464 (93.2) |
53 (10.5) 451 (89.5) |
0.040 | 0.624 (0.398–0.978) | 0.659 |
Ref 0.891 (0.535–1.485) |
|
|
Haplotypes rs2074192/ rs2285666 |
C/C T/C C/T T/T |
210 (42.2) 200 (40.0) 87 (17.4) 2 (0.4) |
236 (46.9) 159 (31.4) 106 (21.0) 3 (0.6) |
0.026 < 0.001 0.049 – |
0.818 (0.685–0.976) 1.448 (1.205–1.741) 0.798 (0.638–0.997) – |
– | – |
Significant values are in bold.
Allele and genotype frequencies are presented as absolute numbers with percentage in parentheses.
OR – odds ratio; CI – confidence interval. Univariate analysis is based on χ2 test. Multivariate analysis is adjusted for gender and age.