Table 3.
Mediation effects of admission NIHSS and baseline GCS scores on the association between night-onset ICH and in-hospital mortality.
| Unadjusted model | Adjusted model | |||
|---|---|---|---|---|
| OR (95% CI) or % (95% CI) | P value | OR (95% CI) or % (95% CI) | P value | |
| Mediating variables: admission NIHSS score | ||||
| Total effect | 1.22 (1.05, 1.40) | 0.0135 | 1.21 (1.01, 1.40) | 0.0361 |
| CDE | 1.11 (0.95, 1.27) | 0.1732 | 1.13 (0.95, 1.31) | 0.1598 |
| NDE | 1.11 (0.95, 1.27) | 0.1732 | 1.12 (0.95, 1.31) | 0.1598 |
| NIE | 1.10 (1.08, 1.12) | < 0.0001 | 1.07 (1.05, 1.09) | < 0.0001 |
| Percentage mediated, % | 50.25 (17.46, 83.04) | 0.0027 | 37.51 (7.89, 67.13) | 0.0131 |
| Percentage due to interaction, % | 20.05 (6.96, 33.14) | 0.0027 | 19.76 (10.45, 29.07) | < 0.0001 |
| Percentage eliminated. % | 65.25 (42.21, 88.29) | < 0.0001 | 52.99 (30.51, 75.46) | < 0.0001 |
| Mediating variables: baseline GCS score | ||||
| Total effect | 1.23 (1.09, 1.38) | 0.0018 | 1.14 (0.99, 1.29) | 0.0639 |
| CDE | 1.10 (0.97, 1.23) | 0.118 | 1.06 (0.92, 1.19) | 0.3981 |
| NDE | 1.10 (0.97, 1.23) | 0.118 | 1.06 (0.92, 1.19) | 0.3981 |
| NIE | 1.12 (1.09, 1.15) | < 0.0001 | 1.08 (1.05, 1.10) | < 0.0001 |
| Percentage mediated, % | 56.07 (27.36, 84.78) | 0.0001 | 58.41 (4.50, 112.32) | 0.0337 |
| Percentage due to interaction, % | 27.56 (9.77, 45.35) | 0.0024 | 22.13 (-6.39, 50.65) | 0.1284 |
| Percentage eliminated. % | 78.47 (64.23, 92.71) | < 0.0001 | 77.30 (47.77, 106.83) | < 0.0001 |
NIHSS National Institutes of Health Stroke Scale, CDE controlled direct effect, NDE natural direct effect, NIE natural indirect effect, GCS Glasgow Coma Scale. Adjusted variables: age, gender, body mass index, systolic blood pressure, diastolic blood pressure, history of subarachnoid hemorrhage, hypertension, diabetes, atrial fibrillation, chronic obstructive pulmonary disease, and fasting blood glucose, homocysteine, creatinine, season and time from onset to arrival.