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. 2026 Mar 28;16:10811. doi: 10.1038/s41598-026-42492-1

Table 1.

Show the comparison comparison of lung disease classification models using chest X-ray images.

Author name Dataset Used algorithm Dataset size Accuracy Advantages Disadvantages
Sanida et al.26 Chest X-ray images (multi-class) Custom CNN with VGG19 architecture 21,165 X-ray images 98.88% High diagnostic accuracy with advanced feature extraction and data augmentation Dataset imbalance required augmentation; computational cost due to architectural complexity
Sunnetci and Alkan26 Chest X-ray images (binary & multi-class) Bag of Features + Multiple Classifiers ~ 10,000 images 99.63% High accuracy using a biphasic majority voting method, user-friendly GUI Limited generalization to unseen data; reliance on predefined feature extraction methods
Shamrat et al.26 Chest X-ray images Fine-tuned MobileNetV2 (MobileLungNetV2) 112,120 X-ray images (ChestX-ray14) 96.97% High classification accuracy; effective use of CLAHE and Gaussian filters for pre-processing; Grad-CAM for visual explanations Computational complexity; requires high computational power due to fine-tuning and large dataset size
Elhanashi et al.26 Chest X-ray images Deep learning (multi-classification and ensemble object detection) Large dataset (not specified in detail) Promising results (accuracy not provided) Enables both classification and localization; employs ensemble models for improved detection; applicable to multiple diseases, including COVID-19 Dataset size and computational requirements not detailed; results compared qualitatively, lacking numerical specificity
Holste et al.26 Chest X-ray images Long-tailed, multi-label classification models 350,000 CXRs Not specified long-tailed and multi-label challenges; includes 26 clinical findings; large-scale benchmark dataset released for research Accuracy metrics not detailed; solutions proposed but lack performance quantification for individual models
Jeong et al.26 Chest X-ray images Optimized ensemble framework for multi-label, long-tailed classification MIMIC-CXR-LT dataset (size not specified) Not specified Addresses multi-label and long-tailed distribution; employs data augmentation and optimized ensemble models; ranks high in the CXR-LT competition Specific accuracy metrics not provided; focused on competition performance, limiting insights for general applications
Sharma et al.26 Chest X-ray images Transfer learning-based deep learning 286 images (rotated through 120° or 140° with 25 augmentations) Not explicitly stated; combination of models displayed the highest prediction accuracy Efficient classification of COVID-19 and other infectious diseases; utilizes transfer learning and image augmentation Small initial dataset size; dependent on image augmentation and transfer learning to generalize
Ravi et al.26 Chest X-ray images Multichannel EfficientNet-based stacking ensemble Not explicitly stated 98% for pediatric pneumonia, 99% for TB, 98% for COVID-19 Robust and generalizable; employs multichannel models (EfficientNetB0, B1, B2); stacked ensemble improves performance Lacks dataset size details; computationally intensive due to multichannel and stacked ensemble architecture
Kim et al.26 Chest X-ray images Transfer learning with EfficientNet v2-M NIH dataset (unspecified size) and SCH dataset (unspecified size) 82.15% (NIH), 82.20% (SCH); per-class accuracy: 63.60%-89.90% End-to-end learning approach; good sensitivity (81.40%) and specificity (up to 94.48%) Lower testing accuracy for certain classes; lack of dataset size details; variable performance across classes
Malik et al.26 Chest X-rays of COVID-19, pneumothorax, pneumonia, lung cancer, and tuberculosis Publicly available benchmark datasets Convolutional Neural Network (CDC Net) with residual network and dilated convolution 99.39%

Highly accurate for multi-class classification

Incorporates residual networks and dilated convolutions

Outperforms pre-trained models (e.g., VGG-19, ResNet-50, Inception v3)

Relies on publicly available datasets, which might not represent real-world diversity

Potential limitations in generalization due to dataset specifics

Alshmrani et al.26 Chest X-rays for COVID-19, Pneumonia, Lung Cancer, Tuberculosis, Lung Opacity, and Normal VGG19 + Convolutional Neural Network (CNN) 3615 COVID-19, 6012 Lung Opacity, 5870 Pneumonia, 20,000 Lung Cancer, 1400 Tuberculosis, 10,192 Normal (total ~ 47,089 images) 96.48%

Combines pre-trained VGG19 with additional CNN layers

High precision and AUC (99.82%)

Superior performance in multi-class classification

Imbalanced dataset sizes may impact generalization

Performance depends heavily on the quality of pre-trained model