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. 2026 Mar 23;34(4):29. doi: 10.32604/or.2026.071617

Table A1. Differential gene analysis.

Gene P val Avg_log2FC Pct.1 Pct.2 P_val_adj Cluster
SLC4A10 6.26 × 10−100 2.27488 0.396 0.223 1.23 × 10−95 0
LTK 1.57 × 10−29 2.18877 0.096 0.044 3.09 × 10−25 0
IL26 1.79 × 10−12 2.51119 0.033 0.014 3.53 × 10−8 0
WNT7A 1.35 × 10−11 2.6382 0.027 0.011 2.65 × 10−7 0
IL22 2.01 × 10−7 2.30399 0.026 0.013 3.95 × 10−3 0
C12orf40 1.96 × 10−6 2.40221 0.025 0.013 3.86 × 10−2 0
AMIGO1 2.48 × 10−6 2.10931 0.032 0.018 4.89 × 10−2 0
UNC45B 2.60 × 10−6 2.0701 0.034 0.019 5.13 × 10−2 0
KRTAP5-7 8.86 × 10−5 2.39987 0.011 0.005 1 0
IL17F 0.001331 2.89805 0.019 0.011 1 0
RP11-277P12.6 0 4.1608 0.726 0.252 0 1
KIR2DL3 0 4.30391 0.615 0.189 0 1
KIR3DL1 0 4.44638 0.564 0.151 0 1
KIR2DL1 0 4.62762 0.516 0.127 0 1
KIR3DL2 0 4.4834 0.518 0.145 0 1
KIR3DL3 0 4.85949 0.355 0.045 0 1
NLRP7 8.45 × 10−19 4.04772 0.035 0.011 1.66 × 10−14 1
PRSS57 1.35 × 10−9 4.35164 0.016 0.005 2.66 × 10−5 1
EPYC 2.48 × 10−8 4.293 0.018 0.006 4.88 × 10−4 1
ZMAT4 0.0027221 4.13486 0.014 0.007 1 1
TRAT1 4.09 × 10−135 1.27612 0.949 0.779 8.05 × 10−131 2
GFPT2 1.52 × 10−7 1.27978 0.17 0.128 3.00 × 10−3 2
ST6GALNAC1 4.28 × 10−6 2.14406 0.016 0.006 8.42 × 10−2 2
CCL1 7.06 × 10−6 2.20308 0.01 0.003 1.39 × 10−1 2
MBOAT4 7.95 × 10−5 1.83741 0.057 0.038 1 2
KRTAP5-7 7.99 × 10−5 1.61294 0.013 0.005 1 2
KRT2 0.0003679 1.9076 0.015 0.007 1 2
NEFM 0.001337 1.2809 0.045 0.031 1 2
WNT7A 0.0030211 1.83001 0.021 0.013 1 2
COL10A1 0.0040608 1.45662 0.014 0.007 1 2
VCY1B 1.33 × 10−213 5.59854 0.103 0.005 2.61 × 10−209 3
CBLN4 4.97 × 10−205 5.63295 0.087 0.003 9.79 × 10−201 3
OCA2 1.83 × 10−177 5.86642 0.111 0.009 3.61 × 10−173 3
OR10J5 4.42 × 10−35 6.23819 0.014 0 8.69 × 10−31 3
RNF186 9.51 × 10−27 6.02052 0.014 0.001 1.87 × 10−22 3
GDPD4 2.67 × 10−26 5.84972 0.016 0.001 5.25 × 10−22 3
CLDN9 2.62 × 10−23 5.91591 0.014 0.001 5.16 × 10−19 3
RBMY1B 1.90 × 10−22 5.86373 0.011 0.001 3.75 × 10−18 3
RBMY1J 2.07 × 10−22 5.67885 0.01 0 4.08 × 10−18 3
UBE2U 8.27 × 10−19 5.65243 0.011 0.001 1.63 × 10−14 3
CD1E 2.74 × 10−233 4.20601 0.662 0.312 1.23 × 10−95 4
CD1B 2.37 × 10−232 4.26644 0.481 0.151 3.09 × 10−25 4
FLT3 1.54 × 10−144 5.1036 0.277 0.076 3.53 × 10−8 4
CACNA2D3 1.50 × 10−62 4.24492 0.167 0.054 2.65 × 10−7 4
CLEC4F 1.57 × 10−41 4.95046 0.104 0.032 3.95 × 10−3 4
XCR1 3.12 × 10−28 4.68302 0.071 0.022 3.86 × 10−2 4
LIPN 2.44 × 10−22 4.44353 0.036 0.008 4.89 × 10−2 4
CD207 8.58 × 10−22 5.31131 0.085 0.033 5.13 × 10−2 4
PPM1J 5.29 × 10−15 4.74916 0.036 0.011 1 4
CCNA1 3.11 × 10−6 4.17339 0.013 0.004 1 4
FOXP3 3.16 × 10−287 4.33154 0.533 0.159 0 5
CCR8 1.57 × 10−244 4.48931 0.537 0.185 0 5
GNG8 2.35 × 10−92 4.06267 0.155 0.034 0 5
CD177 2.81 × 10−37 4.40031 0.157 0.064 0 5
PVALB 8.20 × 10−29 3.94647 0.074 0.022 0 5
AHSP 1.74 × 10−22 4.15447 0.077 0.028 0 5
CD300LD 9.87 × 10−14 4.69525 0.039 0.013 1.66 × 10−14 5
ARX 2.27 × 10−11 5.21748 0.014 0.002 2.66 × 10−5 5
DGKI 1.01 × 10−8 3.86791 0.037 0.015 4.88 × 10−4 5
MYBPC2 2.64 × 10−6 3.93218 0.011 0.003 1 5
IGSF21 2.03 × 10−158 3.92451 0.268 0.056 8.05 × 10−131 6
TMEM26 2.74 × 10−127 3.82477 0.195 0.036 3.00 × 10−3 6
HS3ST2 2.66 × 10−76 3.94625 0.13 0.026 8.42 × 10−2 6
CCL24 9.27 × 10−72 4.28147 0.091 0.014 1.39 × 10−1 6
PKD2L1 1.64 × 10−61 4.31082 0.094 0.017 1 6
TNFSF18 3.96 × 10−13 3.91959 0.042 0.014 1 6
SPINK6 7.46 × 10−12 4.94807 0.011 0.001 1 6
ANKRD66 1.35 × 10−9 4.82224 0.018 0.004 1 6
DUSP27 1.11 × 10−6 4.31534 0.01 0.002 1 6
ACSM4 7.00 × 10−6 3.87344 0.01 0.002 1 6
PAX5 0 6.97256 0.504 0.075 2.61 × 10−209 7
FCRL1 1.64 × 10−269 6.30058 0.502 0.119 9.79 × 10−201 7
CD19 1.56 × 10−250 6.06609 0.494 0.123 3.61 × 10−173 7
FCRLA 1.61 × 10−223 6.14524 0.539 0.168 8.69 × 10−31 7
KHDRBS2 3.87 × 10−51 5.79604 0.113 0.026 1.87 × 10−22 7
KLHL14 7.91 × 10−46 7.12408 0.091 0.019 5.25 × 10−22 7
KCNH8 4.06 × 10−28 5.7496 0.073 0.019 5.16 × 10−19 7
C12orf74 2.48 × 10−23 6.44353 0.039 0.007 3.75 × 10−18 7
FCRL4 9.00 × 10−10 6.27934 0.019 0.004 4.08 × 10−18 7
LCN8 4.08 × 10−9 5.97332 0.014 0.003 1.63 × 10−14 7
IL20 9.89 × 10−10 3.72031 0.018 0.003 1.23 × 10−95 8
CERS1 3.10 × 10−8 3.93585 0.017 0.003 3.09 × 10−25 8
NEUROD4 1.36 × 10−7 7.80849 0.012 0.002 3.53 × 10−8 8
CPNE9 2.02 × 10−7 3.48566 0.027 0.008 2.65 × 10−7 8
OCSTAMP 4.12 × 10−7 5.90075 0.014 0.003 3.95 × 10−3 8
PRPH 6.22 × 10−7 5.74714 0.012 0.002 3.86 × 10−2 8
SHC3 8.99 × 10−7 3.35554 0.026 0.008 4.89 × 10−2 8
RHCG 2.66 × 10−5 3.46443 0.026 0.009 5.13 × 10−2 8
ADGRB3 0.0007539 4.55255 0.011 0.003 1 8
C2orf16 0.0012103 3.84259 0.014 0.005 1 8
KIF15 1.62 × 10−167 4.52638 0.502 0.142 0 9
CDCA5 2.09 × 10−156 4.57741 0.42 0.105 0 9
GTSE1 2.02 × 10−138 4.39905 0.529 0.184 0 9
CDCA2 6.99 × 10−129 4.41556 0.377 0.096 0 9
PLK4 1.74 × 10−124 4.40362 0.301 0.064 0 9
HIST1H3G 3.51 × 10−92 5.06767 0.148 0.021 0 9
E2F8 2.60 × 10−80 4.59759 0.207 0.044 1.66 × 10−14 9
SYCE2 1.14 × 10−42 4.37032 0.096 0.018 2.66 × 10−5 9
GNB3 1.01 × 10−11 4.3892 0.025 0.005 4.88 × 10−4 9
LRIT3 5.95 × 10−11 5.41785 0.011 0.001 1 9
AC109829.1 4.09 × 10−72 6.58454 0.042 0.001 8.05 × 10−131 10
SPACA7 5.54 × 10−68 6.96228 0.034 0.001 3.00 × 10−3 10
C11orf97 1.65 × 10−45 8.79189 0.016 0 8.42 × 10−2 10
PRSS51 7.04 × 10−21 6.8627 0.018 0.001 1.39 × 10−1 10
CT47A10 4.95 × 10−20 6.18936 0.01 0 1 10
KLK4 4.99 × 10−20 7.58343 0.018 0.001 1 10
LRFN5 4.50 × 10−16 6.82028 0.022 0.002 1 10
AC131097.4 6.36 × 10−16 5.9679 0.014 0.001 1 10
SYT8 2.73 × 10−9 6.26022 0.012 0.001 1 10
HSD3B2 3.00 × 10−8 6.12074 0.01 0.001 1 10
POU4F3 4.47 × 10−16 5.03488 0.011 0 2.61 × 10−209 11
CALB2 2.27 × 10−13 4.29152 0.032 0.005 9.79 × 10−201 11
GATA1 3.84 × 10−10 4.20094 0.017 0.002 3.61 × 10−173 11
SERPINB3 1.13 × 10−9 4.48446 0.013 0.001 8.69 × 10−31 11
OR10H1 2.06 × 10−9 6.30405 0.011 0.001 1.87 × 10−22 11
GCM2 1.73 × 10−8 4.46023 0.011 0.001 5.25 × 10−22 11
HRASLS5 8.24 × 10−7 4.25864 0.011 0.001 5.16 × 10−19 11
MUC5AC 8.52 × 10−7 4.64985 0.013 0.002 3.75 × 10−18 11
UBQLNL 0.000152 4.31163 0.019 0.006 4.08 × 10−18 11
FOXL2 0.004164 5.56818 0.011 0.003 1.63 × 10−14 11
KRT82 1.36 × 10−16 3.18133 0.061 0.014 1.23 × 10−95 12
OR5B3 1.41 × 10−15 3.31509 0.035 0.005 3.09 × 10−25 12
PIANP 1.75 × 10−6 3.8333 0.015 0.003 3.53 × 10−8 12
CDC42BPG 1.05 × 10−5 3.18399 0.02 0.005 2.65 × 10−7 12
MAP6 0.0004949 4.32855 0.02 0.006 3.95 × 10−3 12
GJA3 0.0006685 3.28024 0.018 0.005 3.86 × 10−2 12
NCAN 0.0017926 4.20579 0.011 0.003 4.89 × 10−2 12
TRPM1 0.0022167 3.19966 0.063 0.037 5.13 × 10−2 12
FNDC11 0.0025253 4.98432 0.011 0.003 1 12
MYH15 0.0064381 4.25786 0.011 0.003 1 12
PAX4 2.93 × 10−125 7.83822 0.092 0.003 0 13
PDIA2 4.29 × 10−94 6.80038 0.051 0.001 0 13
KRTAP3-1 3.61 × 10−40 7.1002 0.024 0.001 0 13
DEFB103B 1.47 × 10−27 7.01878 0.012 0 0 13
SLC34A3 7.71 × 10−22 6.7498 0.017 0.001 0 13
DEFB103A 1.92 × 10−20 7.20853 0.01 0 0 13
OR5A1 9.30 × 10−17 7.49096 0.012 0 1.66 × 10−14 13
TKTL2 1.26 × 10−11 7.46493 0.017 0.002 2.66 × 10−5 13
TCP11X2 2.96 × 10−11 7.15907 0.017 0.002 4.88 × 10−4 13
NEUROD6 0.0001387 7.53163 0.01 0.002 1 13
SMOC2 6.36 × 10−210 8.24297 0.335 0.021 8.05 × 10−131 14
SOX17 2.02 × 10−186 8.58517 0.216 0.009 3.00 × 10−3 14
FOXF1 2.02 × 10−161 8.80806 0.237 0.013 8.42 × 10−2 14
MYOCD 2.98 × 10−66 8.67703 0.114 0.008 1.39 × 10−1 14
LRRC10B 3.77 × 10−58 8.54747 0.076 0.004 1 14
KRTAP21-2 7.08 × 10−47 8.77569 0.013 0 1 14
JPH2 1.43 × 10−41 8.83149 0.072 0.005 1 14
FOXF2 1.20 × 10−21 8.45481 0.038 0.003 1 14
HSPB7 1.79 × 10−17 8.30385 0.034 0.003 1 14
GABRG1 6.41 × 10−11 8.56627 0.021 0.002 1 14
GAGE12C 0 8.89449 0.991 0.025 2.61 × 10−209 15
GAGE12G 0 8.92961 0.987 0.024 9.79 × 10−201 15
GAGE12J 0 8.96901 0.983 0.024 3.61 × 10−173 15
GAGE12D 0 8.88434 0.983 0.025 8.69 × 10−31 15
GAGE12F 0 8.90395 0.983 0.026 1.87 × 10−22 15
GAGE10 0 8.78936 0.974 0.018 5.25 × 10−22 15
GAGE13 0 8.6895 0.983 0.028 5.16 × 10−19 15
GAGE1 0 8.78731 0.987 0.044 3.75 × 10−18 15
GAGE2E 0 9.31589 0.952 0.016 4.08 × 10−18 15
MAGEA9 7.93 × 10−163 8.61009 0.091 0.001 1.63 × 10−14 15
KCNQ4 2.65 × 10−13 6.83496 0.045 0.003 1.23 × 10−95 16
IFNA10 1.06 × 10−10 6.01285 0.018 0.001 3.09 × 10−25 16
C2orf57 2.37 × 10−9 6.27777 0.018 0.001 3.53 × 10−8 16
FAM43B 6.89 × 10−8 6.31855 0.018 0.001 2.65 × 10−7 16
VSTM2L 9.28 × 10−8 6.36233 0.027 0.002 3.95 × 10−3 16
CHAT 1.70 × 10−7 6.29001 0.018 0.001 3.86 × 10−2 16
SLC17A6 2.76 × 10−6 6.88202 0.018 0.001 4.89 × 10−2 16
ATP13A5 2.88 × 10−6 6.34684 0.018 0.001 5.13 × 10−2 16
PRR22 7.45 × 10−6 5.70779 0.027 0.003 1 16
GRID2 0.002056 5.92001 0.018 0.003 1 16
BRINP2 9.94 × 10−58 8.52739 0.082 0.002 0 17
GPRC6A 7.09 × 10−35 8.34312 0.041 0.001 0 17
ATP2B3 8.53 × 10−15 7.8142 0.041 0.002 0 17
HSPB3 1.58 × 10−13 9.00368 0.01 0 0 17
NR2E1 9.14 × 10−11 7.94249 0.031 0.002 0 17
ASIC5 2.10 × 10−10 8.33298 0.01 0 0 17
AC124312.1 2.10 × 10−10 7.87931 0.01 0 1.66 × 10−14 17
SLC18A3 3.98 × 10−5 8.40139 0.01 0 2.66 × 10−5 17
LRRC71 0.0001071 8.08189 0.01 0.001 4.88 × 10−4 17
PATE2 0.0008554 8.22019 0.01 0.001 1 17