FIGURE 6.

Effect of both depolarization and external [K] on inactivation of the C13 chimera as measured by whole-cell conductance (bar height) after 60 min at the indicated depolarization and external K. The average resting potentials for each external K were −82.6 ± 1 mV at 3 mM K, −55.1 ± 1.4 mV at 10 mM K, −35.2 ± 1.1 at 25 mM K, −21.2 ± 1.1 at 50 mM K, −7.9 ± 1 mV at 75 mM K, and −4.8 ± 1 mV at 100 mM K. All conductances were normalized to the whole-cell conductance after 1-h incubation in the indicated external K. These were defined as unity (leftmost bars in the zero-depolarization row). Error bars on channel activity have been omitted for clarity.