FIGURE 9.

Predicted and experimental effect of mitochondrial Ca²⁺ uptake inhibition on the Ca²⁺ response to 5 mM caffeine (1 s). (A) Predicted values of the decay phase after CAF stimulation, with active (solid line) and inactivated (dashed line) mitochondrial Ca²⁺ uptake. Parameter values are the same as in Fig. 4. (B) Mean [Ca²⁺]_i decay after CAF-induced peak in the absence (n = 21, •) and in the presence (n = 25, ○) of 5 μM FCCP, as a percentage of the control peak, 0 corresponding to baseline.