FIGURE 5.

Our variant of SANC model with the diastolic Ca²⁺ release and adjusted membrane conductance and Ca²⁺ handling parameters to be in line with experimental data (left side marked as + Spontaneous Ca²⁺ Release) and its negative chronotropic response on the complete blockade of the spontaneous release (j_spont = 0) simulating ryanodine effect. Shown are simulated traces for subspace [Ca²⁺], Ca_sub, and membrane potential, V_m, changes. For model parameters see text. T is the action potential period; bpm is beats per min.