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The AP upstroke phase follows the phase of spontaneous Ca2+ release (tphase) upon introduction of spontaneous Ca2+ release into the model. Shown are superimposed simulated traces of [Ca2+] changes in subspace (Casub) along with respective APs generated with varying phase of the diastolic release (tphase, shown at peaks of Casub traces). (Inset) Plot of the first AP period (T) as a function, tphase.
