TABLE 1.

Values of the parameters used in the numerical calculations

Quantity	Symbol	Value	Cell type	Notes
Calcium
Diffusion coefficient	DCa	220 μm2 s−1	Neuroendocrine	Klingauf and Neher (1997)
Background concentration	c0	0.1 μM	–	–
Fixed buffer
Total concentration	[Bf]T	5000 μM	–	See text
Dissociation constant	Kf	10 μM	Neuroendocrine	Klingauf and Neher (1997)
Forward binding rate		5 × 108 M−1 s−1	Neuroendocrine	Klingauf and Neher (1997)
Mobile buffer
Total concentration	[Bm]T	100 μM	Neuroendocrine	Klingauf and Neher (1997)
Dissociation constant	Km	10 μM	Neuroendocrine	Klingauf and Neher (1997)
Forward binding rate		5 × 108 M−1 s−1	Neuroendocrine	Klingauf and Neher (1997)
Diffusion coefficient		15 μm2 s−1	Neuroendocrine	Klingauf and Neher (1997)
BAPTA
Dissociation constant	KB	0.167 μM	–	Smith et al. (1996)
Forward binding rate		6 × 108 M−1 s−1	–	Smith et al. (1996)
Diffusion coefficient	DB	95 μm2 s−1	–	Smith et al. (1996)
Calcium pumps
Pump density	σP	2000 μm−2	Hair cell stereocilia	Yamoah et al. (1998)
Maximum pumping rate	VP	3.2 × 10−11 mol cm−2 s−1	–	Bennett et al. (2000a)
Dissociation constant	KP	0.2 μM	Smooth muscle	Kargacin and Fay (1991)
Exocytosis molecular scheme
Attachment rate	ka	15 × 106 M−1 s−1	Chromaffin, bipolar	Bennett et al. (1997)
Detachment rate	kd	750 s−1	Range of cell types	Bennett et al. (1997)
Conformational change rate	β	2000 s−1	Range of cell types	Bennett et al. (1997)
Facilitation molecular scheme
Low-affinity attachment rate	kon	15 × 106 M−1 s−1	Chromaffin, bipolar	Bennett et al. (1997)
Low-affinity detachment rate	koff	750 s−1	Range of cell types	Bennett et al. (1997)
Release rate	k2	1 × 103 M−1 s−1	–	Tang et al. (2000)
Inactivation rate	k3	1 × 104 s−1	–	Tang et al. (2000)
High-affinity attachment rate	qon	1.85 × 108 M−1 s−1	–	Tang et al. (2000)
High-affinity detachment rate	qoff	555 s−1	–	Tang et al. (2000)
Monte Carlo
Time step	Δt	0.25 μs	–	–
Vesicle disk radius	rV	10 nm	–	–