Fig. 7. CRISPR-engineered DAPS Show Increased Healthy Cartilage Deposition with Minimal Expression of Collagen I and Collagen X.

(A) Representative H&E full-disc image of Large DAPS indicating regions of interest for immunofluorescence. Representative images comparing immunofluorescence for (B) collagen I (green) and collagen II (purple), (C) chondroitin sulfate (proteoglycan, yellow)), and (D) collagen X (orange) deposition within Large DAPS.