FIGURE 7.

Extent of lipid redistribution. Volumes of lipid mass transferred (absolute volume on right ordinate, and relative to total lipid volume on left ordinate) to the “void” from inner (V₁) and outer (V₂) leaflet to minimize the system free energy at each value of r_S. Negative values of V₁ at r_S > 2.3 nm indicate that lipid mass moves back to the inner leaflet, thus making the net movement from the outer to the inner leaflet. Local variations within the curve reflect the difficulty of determining precise free-energy minima with respect to V₁ and V₂, especially for r_S > 2.3 nm.