FIGURE 6.

Desmin plays a role in regulating nuclear shape. (A) Plot of wild-type (pink) and desmin-null (blue) nuclear aspect ratio versus sarcomere length. Aspect ratios are normalized to the aspect ratio at resting sarcomere length. (B) Plot of wild-type (pink) and desmin-null (blue) nuclear length versus sarcomere length. Mean regression slopes are 4.45 for wild-type data and 3.19 for desmin-null data. Differences in nuclear geometry are evident at resting sarcomere length. Different symbols within a color group represent different experiments. Details on statistical differences between groups in this and subsequent figures are provided in text.