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Effect of spheroid radius on molecular uptake. Single cells (▴) or multicellular spheroids of different sizes (•) were electroporated with a single, 38-ms exponential-decay pulse at 0.45 kV/cm bulk field strength. The asterisks indicate that uptake from the three largest spheroid sizes were significantly less than for single cells (t-test, p < 0.05). Average is mean ± SE; n ≥ 3.
