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Models for the phosphorylation steps for CDC25 (A), wee1 (B), CAK (C), and SCF-SKP2 or APC-CDC20 (D). Phosphorylation of CDC25, wee1, and CAK are catalyzed by active cyclin-CDK. SCF-SKP2 or APC-CDC20 (U inactive and U* active in D) is also activated by active cyclin-CDK.
