TABLE 1.

Simulated 1D data, parameter estimation

	1D-I
		Average ± SE		1D-0
	Simulation Parameters	CVF	wSS	Simulation Parameters	Average ± SE
α	333	340 ± 10	453 ± 26	429.8	375 ± 35
β	3000	3177 ± 46	3504 ± 61	3062	3160 ± 137
Kf	314.8	334 ± 11	315 ± 17	35.52	36.8 ± 1.7
Kr	1.85	1.81 ± 0.06	1.84 ± 0.06	1.91	2.27 ± 0.18
τ Desensitization	32.6 ms			30.3 ms
% Desensitization	94.0%			94.3%

Simulation parameters are used to generate each data set. For both models: 100 channels are simulated per set, 300 ms duration, 0.1 ms/point, and 100 points selected evenly along the path of desensitization (tsf = 1, see Methods). No Gaussian noise is added. Averages determined by fitting each data set to the correct model using either CVF or by variance-weighted sum-of-squares minimization (wSS). 1D-I: average of 80 data sets, 1D-0: average of 10 data sets. Desensitization parameters are determined by fitting the smooth curve (generated using the simulation parameters) to a single exponential equation by sum-of-squares minimization.