TABLE 4.

Simulated 2D data, parameter estimation

	2D-II,10-40			2D-II,10-90		2D-I,10-40		2D-I,3-700
	Simulation Parameters	Average ± SE	Simulation Parameters	Average ± SE	Simulation Parameters	Average ± SE	Simulation Parameters	Average ± SE
α	333	381 ± 33	333	373 ± 53	164	149 ± 12	399	385 ± 64
β	3000	3539 ± 133	3000	3380 ± 127	2977	2971 ± 194	3336	3494 ± 164
Kf1	389.2	607 ± 89	389.2	532 ± 107	1016	1109 ± 87	25.32	47 ± 18
Kr1	61.08	85 ± 19	61.08	76 ± 13	2.99	2.93 ± 0.40	0.1014	0.094 ± 0.018
Kf2	496.8	547 ± 43	183.3	203 ± 20	26.5	31.9 ± 6.8	224.7	242 ± 33
Kr2	3.005	2.62 ± 0.24	1.109	1.1 ± 36	61.0	121 ± 50	185.5	201 ± 28
τD1	9.65 ms		10.6 ms		9.75 ms		2.63 ms
%D1	53.6%		42.2%		53.9%		53.9%
τD2	38.8 ms		89.2 ms		39.0 ms		722 ms
%D2	39.6%		53.4%		39.4%		42.8%

For each model, 10 data sets are generated using the simulation parameters. For all data sets, 100 channels are simulated per set and 100 points selected evenly along the path of desensitization (tsf = 1). No Gaussian noise is added. 2D-II,10-40; 2D-II,10-90; and 2D-I,10-40: 300-ms duration, 0.1 ms per point. 2D-I,3-700: 3-s duration, 0.25 ms per point. Averages determined by fitting all 10 data sets to the correct model by CVF. Desensitization parameters are determined by fitting the smooth curve (generated using simulation parameters) to a double exponential equation by sum-of-squares minimization.