TABLE 4.
Representative correlated reaction sets
| Set number | Reaction name | Stoichiometry/Exchange |
|---|---|---|
| 1 | atp | INPUT |
| adp | OUTPUT | |
| 2 | prl1 | rPRL + j2 → rPRLj2 |
| prl2 | rPRLj2 + PRL → rlPRLj2 | |
| prl3 | rlPRLj2 + rPRLj2 + 2 atp → 2 adp + 2PRLj2 | |
| PRL | INPUT | |
| rPRL | INPUT | |
| 2PRLj2 | OUTPUT | |
| 3 | prl4 | 2PRLj2 + stat5A → 2PRLj2s5A |
| prl5 | 2PRLj2s5A + atp → PRLj2s5Ap | |
| prl6 | PRLj2s5Ap → 2PRLj2 + stat5AP + adp | |
| 4 | I4 | INPUT |
| rI4 | INPUT | |
| 5 | il4i | 2I4j1 + stat6 → 2I4j1_s6 |
| il4j | 2I4j1_s6 + atp → I4j1s6p | |
| il4k | I4j1s6p → 2I4j1 + adp + stat6P | |
| 6 | il4l | 2I4j3 + stat6 → 2I4j3_s6 |
| il4m | 2I4j3_s6 + atp → I4j3s6p | |
| il4n | I4j3s6p → 2I4j3 + adp + stat6P |
Each set of reactions always appears together in a set of extreme pathways for the JAK-STAT signaling network. The complete list of correlated reaction sets, as well as the reaction and component abbreviations, are provided in the supplementary material.