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. 2004 Jul;87(1):596–608. doi: 10.1529/biophysj.103.039040

FIGURE 8.

FIGURE 8

Folding kinetics in 0 and 1 M glucose buffers. (Left) Folding rate of λA37G obtained from single exponential fits in 0 M glucose (magenta) and 1 M glucose (cyan). (Black line) Expected slowdown from a ×1.8 increase in bulk viscosity; the rate in 1 M glucose slows down only minimally. (Right) λD14A folding rates. (Upper curves) km in 0 M glucose (magenta) and 1 M glucose (cyan). (Lower curves) ka. The molecular timescale tracks viscosity fully, whereas the activated folding rate again changes only minimally because barrier decrease and viscosity increase compensate.