Table 2. The genomic variants included in the secondary analysis and their prevalence in the UKBB.

Gene	Variant ID	Directly genotyped or imputed	Imputation score R 2a	Chromosome number	Position	Allele 1	Allele 2	Minor allele UKBB	MAF UKBB (unrelated Europeans)
NAT2	rs1041983	Imputed	0.999	chr8	18 257 795	C	T	T	0.33
NAT2	rs1799930	Genotyped	N/A	chr8	18 258 103	G	A	A	0.30
DPP6	rs6977820	Genotyped	N/A	chr7	154 072 020	T	C	T	0.28
COQ2	rs4693075	Genotyped	N/A	chr4	84 192 168	G	C	G	0.38
MC4R	rs489693	Genotyped	N/A	chr18	57 882 787	C	A	A	0.33
GATM	rs1346268	Imputed	1	chr15	45 673 029	T	C	C	0.26
GATM	rs1719247	Imputed	0.995	chr15	45 620 985	C	T	T	0.26
SLCO1B1	rs4149056	Genotyped	N/A	chr12	21 331 549	T	C	C	0.15
ANKK1	rs1800497	Genotyped	N/A	chr11	113 270 828	G	A	A	0.21
CYP2C9	rs1057910	Genotyped	N/A	chr10	96 741 053	A	C	C	0.06

^a R ² is the squared correlation between input genotypes and imputed dosages (that is, true and inferred genotypes). MAF = minor allele frequency. N/A = not applicable (imputation score applies only to imputed variants). UKBB = UK Biobank.