Table 1. Clinical characteristics of the enrolled HC subjects and SFTS patients in the scRNA-seq analysis.
| Participants | Groups | Sex | Age (years) | Days from onset to sampling | Virus load (copies/mL) | Count of platelets (109/L) |
AST (URL) |
LDH (URL) |
CK (URL) |
Neurological symptoms |
Glucocorticoid therapy |
Prognosis |
|
Abbreviations: AST, aspartate aminotransferase; CE, severe cases without glucocorticoid therapy; CK, creatine kinase; F, female; HC, healthy controls; LDH, lactate dehydrogenase; M, male; OR, ordinary SFTS cases; PT, severe cases receiving glucocorticoid therapy; SFTS, severe fever with thrombocytopenia syndrome; URL, upper reference limit. | ||||||||||||
| Matrix1 | HC | M | 55.00 | – | 0 | 185.00 | < 1.00 | < 1.00 | < 1.00 | Negative | – | Health |
| Matrix2 | HC | M | 52.00 | – | 0 | 223.00 | < 1.00 | < 1.00 | < 1.00 | Negative | – | Health |
| Matrix3 | HC | M | 52.00 | – | 0 | 169.00 | < 1.00 | < 1.00 | < 1.00 | Negative | – | Health |
| Matrix4 | OR | M | 76.00 | 5.00 | 7.08 × 105 | 55.00 | 2.86 | 2.51 | 3.42 | Negative | No | Improvement |
| Matrix5 | OR | F | 66.00 | 6.00 | 8.10 × 104 | 63.00 | < 1.00 | 1.22 | < 1.00 | Negative | No | Improvement |
| Matrix6 | OR | F | 53.00 | 5.00 | 1.51 × 105 | 59.00 | 1.04 | 1.32 | 1.35 | Negative | No | Improvement |
| Matrix7 | OR | M | 78.00 | 7.00 | 9.81 × 106 | 79.00 | 4.8 | 3.06 | 1.58 | Negative | No | Improvement |
| Matrix8 | OR | F | 58.00 | 9.00 | 7.82 × 105 | 104.00 | 2.38 | 1.38 | < 1.00 | Negative | No | Improvement |
| Matrix9 | CE | F | 49.00 | 9.00 | 1.40 × 107 | 30.00 | 16.58 | 19.77 | 3.73 | Drowsiness | No | Improvement |
| Matrix10 | CE | M | 61.00 | 6.00 | 4.01 × 107 | 26.00 | 9.39 | 4.05 | 3.02 | Drowsiness | No | Improvement |
| Matrix11 | CE | M | 67.00 | 7.00 | 2.06 × 106 | 78.00 | 7.38 | 3.11 | 2.19 | Tremor | No | Improvement |
| Matrix12 | CE | M | 45.00 | 8.00 | 1.02 × 106 | 75.00 | 1.64 | 1.77 | 1.18 | Convulsions | No | Improvement |
| Matrix13 | CE | F | 76.00 | 10.00 | 7.04 × 107 | 34.00 | 8.65 | 14.24 | 2.70 | Drowsiness | No | Improvement |
| Matrix14 | PT | M | 68.00 | 10.00 | 6.08 × 107 | 35.00 | 41.92 | 11.19 | 4.60 | Drowsiness | Yes | Improvement |
| Matrix15 | PT | M | 47.00 | 7.00 | 5.31 × 106 | 26.00 | 14.93 | 6.1 | 30.82 | Drosiness | Yes | Improvement |
| Matrix16 | PT | F | 67.00 | 5.00 | 3.07 × 107 | 49.00 | 1.82 | 3.31 | 2.83 | Drowsiness | Yes | Improvement |