TABLE 2.

Single-channel parameters for hCt channels in the absence or in the presence of SDS at different concentrations and at fixed hCt concentration

Mode	Λc ± SD (nS)	Occurrence ± SD	Δ%	Activation time (min)
[hCt] = 125 nM	0.014 ± 0.006	2.73 ± 0.09		50
[hCt + SDS] = 125 nM + 0.26 mM	0.013 ± 0.005	3.01 ± 0.11	10.3	16
[hCt + SDS] = 125 nM + 12.5 nM	0.014 ± 0.006	7.49 ± 0.32	174.4	12
[hCt + SDS] = 125 nM + 1.25 nM	0.014 ± 0.008	10.0 ± 0.54	266.3	6
[hCt + SDS] = 125 nM + 0.125 nM	0.013 ± 0.007	11.68 ± 1.07	327.8	5
[hCt + SDS] = 125 nM + 0.0125 nM	0.012 ± 0.004	5.82 ± 0.31	113.2	12

The membranes were formed of POPC/DOPG (85:15), the voltage was set to 150 mV, the aqueous phase contained 1M KCl (pH = 7), and T = 22°C. Δ% = ((occurrence with SDS − occurrence without SDS)/occurrence without SDS)%. The number of events (N_t) considered for each series of experiments was 119 < N_t < 836.