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Effect of histamine on the viscoelastic response of the endothelial cell envelope. (A) Deflection of magnetic bead induced by a sequence of force pulses of T = 2.5 s and F = 1.8 nN. 10 μM of histamine was added into the sample chamber at the time indicated by the arrow. (Note that only partial recovery is observed after 4 min (B)) Analysis of the stiffening caused by histamine in terms of the TVB-model: time evolution of the compliances Ji.
