TABLE 1.
Macroscopic, single channel conductances (γj), and calculated channel numbers for each homotypic and heterotypic connexin combination tested in Xenopus oocyte pairs
| Cx | gobserved (μS)* | γj (pS) | gcorrected (μS)† | No. of channels (×105)‡ |
|---|---|---|---|---|
| mCx45 | 4.05 | 32§¶ | 4.27 | 1.3 |
| rCx32 | 45.2 | 55‖** | 107 | 20.0 |
| rCx43 | 48.8 | 90†† | 130 | 14.8 |
| rCx26 | 42.6 | 135‖** | 94 | 7.1 |
| mCx40 | 54.9 | 198‡‡ | 185 | 9.5 |
| mCx37 | 31.7 | 315§§ | 53 | 2.3 |
| Cx26/Cx32 | 44.8 | 90‖** | 105 | 12.8 |
| Cx37/Cx43 | 35.8 | 140¶¶ | 66 | 5.6 |
gobserved equals the conductance calculated from the voltage difference between the electrodes, and compensation current in the voltage clamp of the cell where the membrane potential is held constant.
gcorrected equals the junctional conductance corrected for cytoplasmic access resistance as estimated in Fig. 5.
N = gcorrected/γj.
Cx43/Cx37 single channel conductances were obtained by the sum of the respective homotypic hemichannel resistances estimated from Traub et al. (1998), Veenstra et al. (1995), and Moreno et al. (1994).