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Predicted effects of calmodulin buffering on peak MLC phosphorylation and Ca2+-CaM-MLCK complex formation. (A) Effect of changing the Ca2+ dissociation constant for the CaM-buffer protein complex on the peak of MLC phosphorylation. (B) Profile of MLC phosphorylation (MLC_P) and Ca2+-CaM-MLCK complex formation (inset) in the presence (solid line) and absence (dotted line) of CaM buffering. Simulations were run at a fixed ligand (100-nM) concentration.
