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. 2004 Sep;87(3):1507–1525. doi: 10.1529/biophysj.104.043299

FIGURE 3.

FIGURE 3

Comparison of simulated (asterisk symbol) versus measured (▵) (Bailly et al., 1998; Kubo and Murata, 2001) IK1 properties. (A) Steady-state current (ordinate, pA/pF) as a function of voltage (abscissa, mV), referred to as an I-V curve, computed by multiplying the activation curve B by whole-cell conductance and electrical driving force. (B) Experimental I-V curve from Fig. 3 in Li et al. (1998). (C) Steady-state open fraction (ordinate) as a function of membrane potential (abscissa, mV) for model IK1 overlaid with experimental measurements obtained from human KCNJ2 channels; from Fig. 2 C in Kubo and Murata (2001). (D) Open channel conductance (ordinate, mS/μF) as a function of extracellular K+ concentration (abscissa, mV). Experimental data from Fig. 2 C in Bailly et al. (1998).