Behavior of the effective dielectric functions, ɛeff-NL(r12, Z0) and ɛeff-CL(r12, Z0), for the NL and classical solvent models, correspondingly, depending on distances Z0 from the protein interface for two charges of interest. (A) The charge orientations are parallel (‖) and (B) perpendicular (⊥) to the interface. Curve 1 indicates the ɛeff-NL(r12, Z0) function. Curve 2 indicates the ɛeff-CL(r12, Z0) function. Calculations were made for the fixed intercharge distances r12 = 3.5 Å.