TABLE A1.

Model parameters

Symbol	Value	Units	Description	Eq.	Ref.
GL	0.0782	mM s−1 V−1	Leak conductance for IMAC	A12	1
Gmax	7.82	mM s−1 V−1	Integral conductance of IMAC at saturation	A12	1
a	1.0 10−3		Basal IMAC conductance	A12
b	1.0 104		Activation factor by cytoplasmic O2·−	A12
κ	70	V−1	Steepness factor	A12	1
	0.004	V	Potential at half saturation	A12	1
Kcc	0.01	mM	Activation constant of IMAC by O2·−	A12
	2.4 106	mM−1 s−1	Second-order rate constant of conversion between native oxidized and reduced superoxide dismutase (SOD)	A3	2
	4.8 104	mM−1 s−1	Second-order rate constant of conversion between native reduced SOD and its inactive form	A3	2
	5.0 10−1	s−1	First-order rate constant for conversion between inactive and active oxidized SOD	A3	2
	0.4 × 10−3–2.5 × 10−3	mM	Intracellular concentration of SOD	A3	2
	0.5	mM	Inhibition constant for H2O2	A3
	1.7 104	mM−1 s−1	Rate constant of catalase (CAT)	A4	3
	0.001	mM	Intracellular concentration of CAT	A4	3
fr	50		Hydrogen peroxide inhibition factor of CAT	A4
	0.00141	mM	Intracellular concentration of glutathione peroxidase (GPX)	A4	4
Φ1	0.15–5.0	mM s	Constant for GPX activity	A5	4
Φ2	0.5	mM s	Constant for GPX activity	A5	4
	1.94	mM	Michaelis constant for oxidized glutathione of glutathione reductase (GR)	A5	5
	38.7	mM	Michaelis constant for NADPH of GR	A6	5
	0.0308	s−1	Rate constant of GR	A6	5
	1.27 10−3	mM	Intracellular concentration of GR	A6	5
GT	1–2	mM	Total intracellular pool of glutathione	A7	6
shunt	0.05		Fraction of respiration diverted to ROS production	A8	37
j	0.12		Fraction of IMAC conductance	A13

¹Borecky et al. (1997).

²McAdam et al. (1977).

³Chance et al. (1979).

⁴Bray et al. (1974).

⁵Carlberg and Mannervik (1985).

⁶Gilbert (1990).

⁷Turrens (2003).