TABLE 1.
Postulated interactions of L45 residues with S5 or S6 residues (β-carbons <7 Å apart)
| L45 residues | S5 or S6 residues |
|---|---|
| Model of open conformation | |
| H378 | L403, F404, I464 |
| S379 | L403, L399, I400 |
| G481 | A465* |
| L382 | A465*, L468*, P473, V474 |
| Q383 | L396 |
| L385 | L468* |
| G386 | L472*, I477 |
| L389 | L472*, F481 |
| S389 | L398* |
| M393 | F484, Y485 |
| Resting conformation (model 1 of Fig. 4) | |
| G381 | I464* |
| L382 | L399, I400, L403, T469, L472, P473 |
| L385 | I464*, V467*, L468*, P473 |
| G386 | L496, P473 |
| T388 | L468* |
| L389 | L468*, A472*, L472*, P473, I477 |
| S392 | L396*, L399*L472*, |
| Resting conformation (model 2, L45 more inward) | |
| G381 | L396, P473 |
| L382 | M393, L396, V476 |
| L385 | V476, I477, N480 |
| G386 | N480 |
| T388 | L472*, P475*, I477, N480 |
| L389 | N480, F481, F484 |
Bold residues are conserved among Kv channels (red, orange, and yellow in Fig. 7 of accompanying article).
*
Interactions are within the same subunit. Residues were considered proximal if the distance between β-carbons was <7 Å.