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. 2026 Mar 20;13:1779221. doi: 10.3389/fmed.2026.1779221

Figure 13.

Grouped medical images comparing radiological and histological findings of a brain tumor. Left: six brain MRI scan types including T2, DWI, ADC, SWI, T1+C, and CBV maps, showing a large lesion in the left hemisphere. Right: high-magnification light micrograph of purple-stained tumor tissue with numerous densely packed cells, scale bar 50 micrometers.

A 31-year-old HIV-positive woman, with classical PCNS-LBCL with dizziness, headaches, and left-sided weakness. The CD4+ lymphocyte count was 250 cells/μL. There was a tumor in the right frontal lobe with intense contrast enhancement, restricted diffusion, and moderate perifocal edema. SWI does not indicate susceptibility artifacts. DSC perfusion results in low CBV values in the mass. Microscopic characteristics: H&E staining scale bar: 50 μm. In hypercellular tumorous tissue with infiltrative growth, cells have a centroblast morphology, and multiple mitoses are present.