FIGURE 1.

Homotetrameric Kv channel: (a) Domain organization of the Shaker B. (b) Homology modeling and docking calculations. (Left) Model of the pore domain. (Right) The four helices, each containing a predicted voltage-sensor segment (green). (c) Projection of a 15 Å slab of the TM domain located below the selectivity filter. The representation shows the charged residues (red) involved in the indicated electrostatic network (dashed red lines), residues of S1–S3 found to be tolerant to side-chain replacements (green) and residues of S5 located at the N-terminus of the pore domain, in contact with the central hydrophilic pathway (blue).