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. 2026 Apr 2;5:23. doi: 10.1038/s44184-026-00203-8

Table. 2.

Five class latent classes of sexual risk, mental health, and polysubstance use among US adolescents, 2021

Latent class indicators Complex high-risk n(%) 2478 (14.6%) Moderate risk experimenters n (%) 2563 (15.1%) Recent polysubstance use/Covid distress n (%) 2068 (12.2%) Low-risk/COVID distress n (%) 2883 (17.0%) Low-risk n (%) 7003 (41.2%)
Alcohol use
Never 0.025 0.417 0.142 0.682 0.832
Ever 0.247 0.368 0.358 0.223 0.124
Recent 0.728 0.214 0.500 0.096 0.044
Marijuana use
Never 0.062 0.673 0.335 0.968 0.980
Ever 0.244 0.200 0.319 0.020 0.014
Recent 0.695 0.127 0.346 0.013 0.006
Cigarette use
Never 0.370 0.859 0.601 0.982 0.985
Ever 0.405 0.133 0.325 0.018 0.015
Recent 0.226 0.008 0.074 0.000 0.000
E-cigarette use
Never 0.047 0.619 0.131 0.929 0.946
Ever 0.164 0.267 0.402 0.070 0.049
Recent 0.788 0.114 0.467 0.001 0.005
Feeling depressed
No 0.263 0.577 0.357 0.138 0.933
Yes 0.737 0.423 0.643 0.862 0.067
Suicidal ideation
No 0.490 0.799 0.651 0.583 0.991
Yes 0.510 0.201 0.349 0.417 0.009
Age of first sex
Never 0.000 0.000 1.000 1.000 1.000
11 to 13 0.275 0.153 0.000 0.000 0.000
14 0.274 0.184 0.000 0.000 0.000
15 0.232 0.264 0.000 0.000 0.000
16 or older 0.219 0.399 0.000 0.000 0.000
Number of partners
None 0.000 0.000 1.000 1.000 1.000
1 0.335 0.640 0.000 0.000 0.000
2 0.214 0.168 0.000 0.000 0.000
3 or more 0.451 0.192 0.000 0.000 0.000
Drugs/alcohol last sex
Never had sex 0.000 0.000 1.000 1.000 1.000
Yes 0.340 0.039 0.000 0.000 0.000
No 0.660 0.961 0.000 0.000 0.000
Condom use last sex
Never had sex 0.000 0.000 1.000 1.000 1.000
Yes 0.430 0.648 0.000 0.000 0.000
No 0.570 0.352 0.000 0.000 0.000
COVID MH
Never/rarely 0.210 0.383 0.228 0.045 0.633
Sometimes 0.183 0.295 0.250 0.233 0.269
Most of the time/always 0.606 0.323 0.522 0.722 0.098
Parent COVID job loss
No 0.650 0.743 0.670 0.739 0.835
Yes 0.350 0.257 0.330 0.261 0.165

*Latent class definitions: Class 1—not sexually active and did not use substances; Class 2—polysubstance experimenters; Class 3—not sexually active but polysubstance users with suicidal ideation and depression; Class 4—engaged in sexual risk behaviors and polysubstance use.