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. 2004 Oct;87(4):2714–2722. doi: 10.1529/biophysj.104.040162

FIGURE 3.

FIGURE 3

Structures of a conformational switch in peptidyl transferase center and the sarcin/ricin loop. (a) Pretranslocation (cyan), modeled (pink), and targeted (green) structures of the 23S PTC regions are plotted alongside with C-74 and C-75 of the P-site tRNA. 23S rRNA G-2251 and G-2252 interact with C-74 and C-75 of P-site tRNA. (b) In the D. radiodurans-based model, U-2249 interacts with G-2253 and G-2255. In the H. marismortu-based model, U-2249 interacts with C-2254. (c) Both the NMR derived (cyan) and the x-ray derived (green) structures of the isolated SRL are more extended than the modeled SRL (pink) in the ribosome.