Intersubunit bridge interactions. (a) Surface of domain IV (pink) of the 23S rRNA has a structural indentation that is complementary to helix 44. (b) Bridges B2a, B3, and B5 are highlighted in white and green, respectively, for residues from 16S helix 44 and 23S domain IV. (c) Stereo plot of the bridge B2a. (d) Stereo plot of the bridge B3. (e) Stereo plot of the bridge B5. In panels c–e, 16S rRNA is shown in white (nonbridging nucleotides) and cyan (bridging nucleotides), and the 23S rRNA is shown in magenta (nonbridging nucleotides) and green (bridging nucleotides).