TABLE 1.
Summary of the physical characteristics considered for the lipid vesicles prepared with a variable sterol mol fraction
| Sterol mol fraction
|
|||||
|---|---|---|---|---|---|
| 0 | 0.075 | 0.10 | 0.15 | 0.30 | |
| AS (nm2) | 0.63 | 0.59 | 0.58 | 0.56 | 0.48 |
| μ* | 92,074 | 97,901 | 100,011 | 104,516 | 120,847 |
The calculation of the average number of lipids in a single liposome, μ, was made assuming a homogeneous population of spherical lipid vesicles with an external diameter of 100 nm and a bilayer thickness of 4.0 nm. The condensing effect of cholesterol was taken into account by considering a variable average cross-sectional molecular area, AS (Smaby et al., 1997). It was further assumed that ergosterol had a similar effect to cholesterol on the physical properties of the lipid bilayers.